MORPHOLOGICAL EVALUATION OF CISPLATIN-INDUCED TESTICULAR DAMAGE IN WISTAR RATS

Twenty-one Wistar rats weighing 200 - 250 mg were categorized into three treatment groups- the control, saline and cisplatin groups, each comprising of seven per group, to assess effects cisplatin-induced testicular damage in rats. The control group received feed mash water ad libitum, equal volumes physiological intraperitoneally with normal feeds water, while cisplastin 8 mg/kg body weight only for five days had twelve weeks before sacrifice. these treatments on total sperm count, motility, percentage live:dead epididymal morphology assessed. results revealed count as significantly different from (p<0.001), motile was also (p<0.001). Also, there a greater dead more morphologically abnormal forms compared control. sections showed progression spermatogenic germ cell series interstitium. testes seminiferous tubules atrophic changes, detached basement membrane epithelium, inflammed interstitium oedema, paucity Leydig cells, vascular congestion haemorrhage. epididymis lumen empty or scanty spermatozoa, necrosis These findings affirms reality severe gonadotoxicity associated use chemotherapeutic agent, especially male.